This antibody can be used for detection of Zika, Dengue, West Nile, and Japanese Encephalitis virus. It binds to the fusion loop at the extremity of domain II of centrosome-associated protein E (epitope is highly conserved amongst Flaviviridae) and allows to identify cells infected with these virises. Exciting developmet - use of Zika virus for treatment of glyoblastoma cancer was recently suggested. Read more...
The family Flaviviridae, named from the Latin “flavus” for the hallmark jaundice caused by infection with yellow fever virus (YFV). The flavivirus group includes more than 70 viruses.
Arboviruses (arbovirus is an acronym (ARthropod-BOrne virus) within this genus are transmitted by a variety of mosquito species as well as ixodid and argasid ticks.
Zika virus is a mosquito-borne flavivirus that was first identified in Uganda in 1947 in monkeys through a network that monitored yellow fever. In 1952 it was later identified in humans. From the 1960s to 1980s, outbreaks of Zika virus disease have been recorded in Africa, the Americas, Asia and the Pacific, typically accompanied by mild illness. In 2007, the first large outbreak of disease caused by Zika infection was reported from the Island of Yap (Federated States of Micronesia). An association between Zika virus infection, Guillain-Barré syndrome and microcephaly was reported in Brazil.
Dengue virus (DENV) is the cause of dengue fever. It is also a mosquito-borne virus of the family Flaviviridae; genus Flavivirus] It has been estimated that over half of the global population is at risk for infection with one of four dengue virus serotypes (DENV-1, -2, -3, and -4), and YFV, DENV, JEV, and WNV collectively cause millions of infections and tens of thousands of deaths each year.